Aberrant methylation patterns in cancer: a clinical view     

Alja Videtic Paska  Petra Hudler 《Biochemia medica : ?asopis Hrvatskoga dru?tva medicinskih biokemi?ara / HDMB》2015,25(2):161-176

Epigenetic mechanisms, such as DNA methylation, DNA hydroxymethylation, post-translational modifications (PTMs) of histone proteins affecting nucleosome remodelling, and regulation by small and large non-coding RNAs (ncRNAs) work in concert with cis and trans acting elements to drive appropriate gene expression. Advances in detection methods and development of dedicated platforms and methylation arrays resulted in an explosion of information on aberrantly methylated sequences linking deviations in epigenetic landscape with the initiation and progression of complex diseases. Here, we consider how DNA methylation changes in malignancies, such as breast, pancreatic, colorectal, and gastric cancer could be exploited for the purpose of developing specific diagnostic tools. DNA methylation changes can be applicable as biomarkers for detection of malignant disease in easily accessible tissues. Methylation signatures are already proving to be an important marker for determination of drug sensitivity. Even more, promoter methylation patterns of some genes, such as MGMT, SHOX2, and SEPT9, have already been translated into commercial clinical assays aiding in patient assessment as adjunct diagnostic tools. In conclusion, the changes in DNA methylation patterns in tumour cells are slowly gaining entrance into routine diagnostic tests as promising biomarkers and as potential therapeutic targets.Key words: biomarkers, CpG islands, DNA methylation, molecular diagnostics, epigenetics  相似文献   

Mental rotation performance in fourth graders: No effects of gender beliefs (yet?)     

Corinna Titze  Petra Jansen  Martin Heil 《Learning and individual differences》2010,20(5):459-463

The influence of gender beliefs on cognitive task performance has been demonstrated repeatedly for adults. For children, there is evidence that gender beliefs can substantially impede or boost math performance — a task where gender differences in favour of boys declined over past decades. Therefore, we examined this phenomenon using the Mental Rotations Test (MRT), a task where gender differences still occur reliably favouring males — for adults as well as for children. A sample of 252 fourth graders, whose beliefs about spatial ability were manipulated experimentally (instructions given: boys are better, girls are better or independent of gender) had to complete the MRT. In contrast to adult's literature, children's performance did not decrease or increase as a function of instruction: boys always outperformed girls; girls not even outperformed their same-sex counterparts given the “girls better” instruction. The transfer of the conceptual approach failed — possible reasons are discussed.  相似文献   

The psychotherapist and the sign language interpreter     

de Bruin E  Brugmans P 《Journal of deaf studies and deaf education》2006,11(3):360-368

Specialized psychotherapy for deaf people in the Dutch and Western European mental health systems is still a rather young specialism. A key policy principle in Dutch mental health care for the deaf is that they should receive treatment in the language most accessible to them, which is usually Dutch Sign Language (Nederlandse Gebarentaal or NGT). Although psychotherapists for the deaf are trained to use sign language, situations will always arise in which a sign language interpreter is needed. Most psychotherapists have the opinion that working with a sign language interpreter in therapy sessions can be a valuable alternative option but also see it as a second-best solution because of its impact on the therapeutic process. This paper describes our years of collaborationship as a therapist and a sign language interpreter. If this collaborationship is optimal, it can generate a certain "therapeutic power" in the therapy sessions. Achieving this depends largely on the interplay between the therapist and the interpreter, which in our case is the result of literature research and our experiences during the last 17 years. We analyze this special collaborative relationship, which has several dimensions and recurrent themes like, the role conception of the interpreter, situational interpreting, organizing the interpretation setting, or managing therapeutic phenomena during therapy sessions.  相似文献   

How to conduct research on the inherent moral significance of teaching: A phenomenological elaboration of the standard repertory grid application     

Carlos A. van Kan  Petra Ponte  Nico Verloop 《Teaching and Teacher Education》2010,26(8):1553-1562

George Kelly’s repertory grid application seems a promising method for researching the moral significance of teaching from a ‘life world’ perspective. However, we encountered several challenges employing the repertory grid in its standard form for an inquiry into the inherent moral significance of teachers’ everyday classroom interactions. In this article we will set out in detail how, on the basis of the standard repertory grid application, we developed a repertory interview method that can be used to collect data that could foster a thorough understanding of the inherent moral significance of teachers’ day-to-day classroom interactions.  相似文献   

考察阶段模型的阶段性假说-一项银行员工体育锻炼行为的实证研究          下载免费PDF全文

段艳平  鲍政栋  Petra Wagner  Walter Brehm 《武汉体育学院学报》2009,43(12):54

本研究运用"柏林锻炼阶段"模型调查了211名银行员工的体育锻炼行为,并通过检验银行员工的锻炼自我效能变量和社会支持变量在各阶段中的非连续性模式和非线性趋势,考察了该阶段模型的阶段性假说.研究结果没有充分支持上述阶段性假说.未来研究仍需进一步修订该阶段模型.  相似文献   

Teacher Education for Inclusive Education Call for manuscripts for a special issue of the European Journal of Special Needs Education to be published in 2013     

Petra Engelbrecht 《欧洲特需教育杂志》2013,28(2)

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Aussteigen oder dabeibleiben? Determinanten der Aufrechterhaltung sportlicher Aktivität in gesundheitsorientierten Sportprogrammen     

Petra Wagner  Dorothee Alfermann 《Sportwissenschaft》2000,30(3):354-356

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Adult Education between Cultural Assimilation and Structural Integration. Settlement programmes for 'newcomers' in The Netherlands     

Petra Schedler  Folke Glastra 《Compare》2000,30(1):53-66

In The Netherlands, since 1996, 'newcomers', like migrants, refugees and asylum seekers, are obliged to take part in an educational settlement programme which should enable them to gain access to (professional) education and to the labour market. This paper deals with the settlement efforts that are required from adult education on the one hand and newcomers on the other hand, and with the current results and further prospects. We elaborate the central aspects of the settlement policy and its developments, and, drawing on the field theory of Pierre Bourdieu, we analyse the settlement policy and its consequences for adult education as well as newcomers. Then we turn to the two ideologies, cultural assimilation and structural integration, which firmly instigated the (re)formation of the policy, and we relate them to the actual settlement practice. Conclusively, we stipulate three kinds of conditions for a settlement policy that has greater significance for the labour participation of newcomers, and for their integration in Dutch society in general.  相似文献   

Bewegungskorrektur im Sportunterricht     

Petra Wolters  Dietrich Kurz 《Sportwissenschaft》2000,30(2):238-240

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Perspectives and Profiles     

Siegfried Nagel  Petra Wolters 《Sportwissenschaft》2002,32(1):113-116

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